Applications of Fluorescence in Situ Hybridisation (FISH) for the Identification of Chromosomal Aberrations in Haematological Malignancy
Speaker
Dr Chin Loi Khim, Pathologist (Genetics),
Head of Genetics Laboratory, Hospital Tunku Azizah, Kuala Lumpur
Lecture Objectives
The objective of this scientific and educational webinar is to introduce the possible applications of cytogenetics (especially FISH) in the evaluation of haematological malignancy with a focus on AML. This webinar will also share the clinical case studies to illustrate how different types of cytogenetics testing may be used in the evaluation and direct the subsequent targeted treatment for haematological malignancy.
FISH technique being an integral part of the cytogenetics laboratory has been accepted as standard practice for the study of chromosomal aberrations. FISH is essential for the characterisation of chromosome rearrangements, marker chromosomes, microdeletions and the diagnosis of common aneuploidies, as well as the detection of prognostic or predictive chromosomal abnormalities in haematological neoplasms. In addition, FISH is also utilised for investigating the origin and progression of haematological malignancies. Therefore, in the management of haematological neoplasms with chromosomal aberrations, FISH has become an indispensable tool.
Abstract
Rapidly developing field of genetic technology and its application in the management of haematological malignancies have bought significant improvement in treatment and outcome of these disorders. Today, genetics play a pivotal role in diagnosis and prognostication of most haematological neoplasms. The utilisation of genetic tests in deciding specific treatment of various haematological malignancies as well as for evaluation of depth of treatment response is swiftly advancing.
FISH technique being an integral part of the cytogenetics laboratory has been accepted as standard practice for the study of chromosomal aberrations. FISH is essential for the characterisation of chromosome rearrangements, marker chromosomes, microdeletions and the diagnosis of common aneuploidies, as well as the detection of prognostic or predictive chromosomal abnormalities in haematological neoplasms. In addition, FISH is also utilised for investigating the origin and progression of haematological malignancies. Therefore, in the management of haematological neoplasms with chromosomal aberrations, FISH has become an indispensable tool.
We hoped you have enjoyed the webinar and gained new insights!
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